Feng Tao, Cai Xiang-Hai, Li Yan, Wang Yuan-Yuan, Liu Ya-Ping, Xie Ming-Jin, Luo Xiao-Dong
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China.
Org Lett. 2009 Nov 5;11(21):4834-7. doi: 10.1021/ol9018826.
A phytochemical study on Melodinus henryi has led to the isolation of two novel alkaloids, melohenines A (1), a monoterpenoid indole alkaloid with additional skeletal carbons arranged compactly in eight rings, and melohenine B (2), an alkaloid with an unprecedented 6/9/6/6 tetracyclic ring system regarded as a key intermediate from indole to quinoline alkaloids. Their structures were elucidated by means of spectroscopic methods and further confirmed by X-ray diffraction analysis.
对川滇崖豆藤的植物化学研究导致分离出两种新型生物碱，即崖豆藤碱A（1），一种单萜吲哚生物碱，其额外的骨架碳紧密排列成八个环；以及崖豆藤碱B（2），一种具有前所未有的6/9/6/6四环系统的生物碱，被认为是从吲哚生物碱到喹啉生物碱的关键中间体。它们的结构通过光谱方法阐明，并通过X射线衍射分析进一步证实。
