密罗通宁 A，一种来自密罗木的细胞毒性单萜吲哚生物碱。

Melotenine A, a cytotoxic monoterpenoid indole alkaloid from Melodinus tenuicaudatus.

机构信息

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China.

出版信息

Org Lett. 2010 Mar 5;12(5):968-71. doi: 10.1021/ol1000022.

DOI:10.1021/ol1000022

PMID:20112938

Abstract

Melotenine A (1), an unprecedented skeleton with a 6/5/5/6/7 pentacyclic rearranged ring system, was isolated from Melodinus tenuicaudatus. The structure was elucidated by means of spectroscopic methods and further confirmed by the single-crystal X-ray diffraction analysis. A possible biogenesis was also proposed. Melotenine A exhibited potential inhibition against five human cancer cell lines.

摘要

从密蒙花中分离得到了一个前所未有的具有 6/5/5/6/7 个五员环重排骨架的倍半萜 Melotenine A（1）。通过光谱方法阐明了其结构，并通过单晶 X 射线衍射分析进一步证实。还提出了可能的生源途径。Melotenine A 对五种人癌细胞系表现出潜在的抑制作用。