State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China.
Org Lett. 2010 Mar 5;12(5):968-71. doi: 10.1021/ol1000022.
Melotenine A (1), an unprecedented skeleton with a 6/5/5/6/7 pentacyclic rearranged ring system, was isolated from Melodinus tenuicaudatus. The structure was elucidated by means of spectroscopic methods and further confirmed by the single-crystal X-ray diffraction analysis. A possible biogenesis was also proposed. Melotenine A exhibited potential inhibition against five human cancer cell lines.
从密蒙花中分离得到了一个前所未有的具有 6/5/5/6/7 个五员环重排骨架的倍半萜 Melotenine A（1）。通过光谱方法阐明了其结构，并通过单晶 X 射线衍射分析进一步证实。还提出了可能的生源途径。Melotenine A 对五种人癌细胞系表现出潜在的抑制作用。
