State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
University of Chinese Academy of Sciences, Beijing 100049, China.
Org Lett. 2020 Oct 2;22(19):7676-7680. doi: 10.1021/acs.orglett.0c02871. Epub 2020 Sep 21.
Meloyunnanines A-C, three alkaloids with an unprecedented skeleton, were isolated from fruits of . The structures featuring a caged-6/6/5/6/5/5 ring system were elucidated by the analysis of comprehensive spectroscopic and X-ray data. Biosynthetically, meloyunnanines A-C were assigned to monoterpenoid quinoline alkaloids (MQAs), derived from monoterpenoid indole alkaloids through oxidation and rearrangement. These compounds together with three known MQAs were evaluated for their neurotrophic activity and scandine -oxide exhibited significant effect.
梅尔油兰宁 A-C，三种具有前所未有的骨架的生物碱，从. 的果实中分离得到。通过综合光谱和 X 射线数据分析，阐明了具有笼状 6/6/5/6/5/5 环系的结构。生物合成上，梅尔油兰宁 A-C 被分配到单萜喹啉生物碱（MQAs），通过氧化和重排从单萜吲哚生物碱衍生而来。这些化合物与三种已知的 MQAs 一起评估了它们的神经营养活性，氧化石杉碱表现出显著的效果。
