Faculty of Science, Division of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, The Netherlands.
Biomarkers. 2009 Nov;14(7):523-8. doi: 10.3109/13547500903150763.
Inflammation has been identified as an important factor for disease exacerbation in obstructive lung disease. In this study, we used neutrophil and eosinophil counts as biomarkers for exacerbation in obstructive lung disease. We conducted a case-control study within a cohort of patients frequenting an outpatient clinic of Respiratory Medicine using data from the Utrecht Patient Oriented Database (UPOD). Cases were patients with a hospital admission for obstructive lung disease in 2005. For each case, one control patient was sampled from the same study base. We identified 143 cases (118 patients with chronic obstructive pulmonary disease and 25 asthma patients) and 143 controls. Admission was associated with both neutrophilia (adjusted odds ratio (OR) 4.3; 95% confidence interval (CI) 2.2-8.5), and eosinophilia (adjusted OR 2.6; 95% CI 1.1-6.2). The association with eosinophilia was only seen in asthma patients. In conclusion, neutrophil and eosinophil counts seem to be useful biomarkers for identifying exacerbations in pharmacoepidemiological studies on obstructive lung disease.
炎症已被确定为阻塞性肺疾病恶化的一个重要因素。在这项研究中，我们使用中性粒细胞和嗜酸性粒细胞计数作为阻塞性肺疾病恶化的生物标志物。我们在呼吸医学门诊的患者队列中进行了一项病例对照研究，使用了乌得勒支患者为中心数据库（UPOD）的数据。病例是 2005 年因阻塞性肺疾病住院的患者。对于每个病例，从同一研究基础中抽取一名对照患者。我们确定了 143 例（118 例慢性阻塞性肺疾病患者和 25 例哮喘患者）和 143 名对照者。入院与中性粒细胞增多症（调整后的优势比（OR）4.3；95%置信区间（CI）2.2-8.5）和嗜酸性粒细胞增多症（调整后的 OR 2.6；95% CI 1.1-6.2）有关。嗜酸性粒细胞增多与哮喘患者有关。总之，中性粒细胞和嗜酸性粒细胞计数似乎是识别阻塞性肺疾病药物流行病学研究中恶化的有用生物标志物。
