结核杆菌蜡质在引发迟发型超敏反应（即对蛋白质抗原卵清蛋白的超敏反应）中的作用。
The role of the wax of the tubercle bacillus in establishing delayed hypersensitivity, hypersensitivity to a protein antigen, egg albumin.
作者信息
RAFFEL S, ARNAUD L E
出版信息
J Exp Med. 1949 Jul;90(1):53-72. doi: 10.1084/jem.90.1.53.
Abstract
Guinea pigs sensitized with egg albumin along with the purified wax fraction of the human tubercle bacillus respond with delayed hypersensitive reactivity to the protein antigen. Previous publications have reported a similar activity of the wax with respect to tuberculoprotein and picryl chloride. The effect is not referable to an ordinary adjuvant activity of the bacillary wax, since antibody titers are not increased in animals which receive it, and since a known adjuvant, water-in-oil emulsion, has no effect with respect to the induction of delayed hypersensitivity. This report further extends the rôle of the tubercle bacillary wax in the induction of delayed hypersensitive states.
摘要
用卵白蛋白以及人结核杆菌的纯化蜡质部分致敏的豚鼠，对蛋白质抗原有迟发型超敏反应。以前的出版物报道了蜡质对结核蛋白和苦味酸氯有类似的活性。这种作用并非归因于杆菌蜡质的普通佐剂活性，因为接受它的动物抗体滴度并未增加，而且已知的佐剂油包水乳剂对迟发型超敏反应的诱导没有作用。本报告进一步扩展了结核杆菌蜡质在迟发型超敏状态诱导中的作用。
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The role of the wax of the tubercle bacillus in establishing delayed hypersensitivity, hypersensitivity to a protein antigen, egg albumin.结核杆菌蜡质在引发迟发型超敏反应（即对蛋白质抗原卵清蛋白的超敏反应）中的作用。
J Exp Med. 1949 Jul;90(1):53-72. doi: 10.1084/jem.90.1.53.
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J Exp Med. 1948 Oct 1;88(4):485-502. doi: 10.1084/jem.88.4.485.
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