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用甲磺酸甲酯处理后染色质中DNA修复的非均匀分布。

Nonuniform distribution of DNA repair in chromatin after treatment with methyl methanesulfonate.

作者信息

Bodell W J

出版信息

Nucleic Acids Res. 1977 Aug;4(8):2619-28. doi: 10.1093/nar/4.8.2619.

DOI:10.1093/nar/4.8.2619
PMID:198747
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC342596/
Abstract

The distribution of methyl methanesulfonate induced DNA repair was measured in mouse mammary cell chromatin by digestion of "repair labeled" nuclei with micrococcal nuclease. The results indicate that there is a nonuniform distribution of DNA repair in chromatin. The chromatin fraction digested during the first 5 minutes of incubation with micrococcal nuclease appears to be a primary site of DNA repair after methyl methanesulfoante treatment. The observed nonuniform distribution of DNA repair in chromatin may be due to 1)a nonrandom alkylation of DNA in chromatin by methyl methanesulfonate or 2)areas in chromatin of increased accessibility for the repair enzymes to the DNA lesions.

摘要

通过用微球菌核酸酶消化“修复标记”的细胞核，测定了甲磺酸甲酯诱导的DNA修复在小鼠乳腺细胞染色质中的分布。结果表明，染色质中DNA修复的分布不均匀。在用微球菌核酸酶孵育的最初5分钟内被消化的染色质部分似乎是甲磺酸甲酯处理后DNA修复的主要位点。在染色质中观察到的DNA修复分布不均匀可能是由于：1）甲磺酸甲酯对染色质中DNA的非随机烷基化，或2）染色质中修复酶对DNA损伤的可及性增加的区域。

相似文献

1
Nonuniform distribution of DNA repair in chromatin after treatment with methyl methanesulfonate.用甲磺酸甲酯处理后染色质中DNA修复的非均匀分布。
Nucleic Acids Res. 1977 Aug;4(8):2619-28. doi: 10.1093/nar/4.8.2619.
2
The influence of chromatin structure on the distribution of DNA repair synthesis studied by nuclease digestion.通过核酸酶消化研究染色质结构对DNA修复合成分布的影响。
Nucleic Acids Res. 1979 Jan;6(1):359-70. doi: 10.1093/nar/6.1.359.
3
Reduced DNA repair in mouse satellite DNA after treatment with methylmethanesulfonate, and N-methyl-N-nitrosourea.用甲磺酸甲酯和N-甲基-N-亚硝基脲处理后，小鼠卫星DNA中的DNA修复减少。
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4
Nuclease sensitivity of repair-incorporated nucleotides in chromatin and nucleosome rearrangement in human cells damaged by methyl methanesulfonate and methylnitrosourea.甲磺酸甲酯和甲基亚硝基脲损伤的人类细胞中染色质修复掺入核苷酸的核酸酶敏感性及核小体重排
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5
Repair replication of DNA in the intact animal following treatment with dimethylnitrosamine and with methyl methanesulphonate, studied by fractionation of nuclei in a zonal centrifuge.用二甲基亚硝胺和甲磺酸甲酯处理完整动物后，通过区带离心法对细胞核进行分级分离，研究DNA的修复复制情况。
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In vitro rabbit mammary gland chromatin replication studied by micrococcal nuclease digestion.通过微球菌核酸酶消化研究体外兔乳腺染色质复制。
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Inhibition of deoxyribonucleic acid synthesis and replicon elongation in mammalian cells-exposed to methyl methanesulfonate.暴露于甲磺酸甲酯的哺乳动物细胞中脱氧核糖核酸合成及复制子延伸的抑制作用
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Carcinogen-induced DNA repair in nucleotide-permeable Escherichia coli cells. Induction of DNA repair by the carcinogens methyl and ethyl nitrosourea and methyl methanesulfonate.致癌物诱导的核苷酸可通透大肠杆菌细胞中的DNA修复。致癌物甲基亚硝基脲、乙基亚硝基脲和甲磺酸甲酯对DNA修复的诱导作用。
Eur J Biochem. 1975 Aug 15;56(2):433-47. doi: 10.1111/j.1432-1033.1975.tb02250.x.
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Carcinogen-induced DNA repair in primary rat liver cell cultures; a possible screen for chemical carcinogens.致癌物诱导的原代大鼠肝细胞培养物中的DNA修复；一种潜在的化学致癌物筛选方法。
Cancer Lett. 1976 Mar;1(4):231-5. doi: 10.1016/s0304-3835(75)97171-2.

引用本文的文献

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The use of radioimmunoassay to study the formation and disappearance of O6-methylguanine in mouse liver satellite and main-band DNA following dimethylnitrosamine administration.使用放射免疫分析法研究二甲基亚硝胺给药后小鼠肝脏卫星DNA和主带DNA中O6-甲基鸟嘌呤的形成与消失。
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Cellular and molecular aspects of immune system aging.免疫系统衰老的细胞和分子层面
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Nucleic Acids Res. 1979 Nov 10;7(5):1343-61. doi: 10.1093/nar/7.5.1343.

本文引用的文献

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Increased repair in DNA growing point regions after treatment of human lymphoma cells with N-methyl-N'-nitro-N-nitrosoguanidine.用N-甲基-N'-硝基-N-亚硝基胍处理人淋巴瘤细胞后，DNA生长点区域的修复增加。
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Heterochromatin and chromosome aberrations.异染色质与染色体畸变。
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