Institute for Medical Research, Department for Nutrition and Metabolism, University of Belgrade, Tadeusa Koscuska 1, 11129 Belgrade, Serbia.
J Clin Biochem Nutr. 2009 Nov;45(3):370-5. doi: 10.3164/jcbn.09-54. Epub 2009 Oct 28.
Nutritional and immunological status of patients with obstructive jaundice is usually severely altered, with high mortality rates. The n-3 polyunsaturate fatty acids (PUFA), particularly eicosapentaenoic acid (EPA, 20:5 n-3), posess potent immunomodulatory activities. Thus, our aim was to compare the plasma phospholipid fatty acid (FA) composition of these patients with healthy subjects, as well as before and after 7 days preoperative supplementation with high doses of EPA (0.9 g per day) and docosahexaenoic acid (DHA, 22:6 n-3, 0.6 g per day). We found impaired FA status in obstructive jaundice patients, especially EPA, DHA and PUFA, but significantly increased content of total n-3 FA, 22:5 n-3 FA and particularly EPA, which increased more than 3 fold, after 7 days supplementation. In addition, the n6/n3 ratio significantly decreased from 14.24 to 10.24, demonstrating severely improved plasma phospholipid profile in these patients after the intervention.
梗阻性黄疸患者的营养和免疫状态通常严重改变，死亡率高。n-3 多不饱和脂肪酸（PUFA），特别是二十碳五烯酸（EPA，20:5 n-3），具有很强的免疫调节作用。因此，我们的目的是比较这些患者与健康受试者的血浆磷脂脂肪酸（FA）组成，以及在术前 7 天补充高剂量 EPA（每天 0.9 克）和二十二碳六烯酸（DHA，22:6 n-3，每天 0.6 克）前后的 FA 组成。我们发现梗阻性黄疸患者的 FA 状态受损，特别是 EPA、DHA 和 PUFA，但在 7 天补充后，总 n-3 FA、22:5 n-3 FA，特别是 EPA 的含量显著增加，增加了 3 倍以上。此外，n6/n3 比值从 14.24 显著降低到 10.24，表明这些患者在干预后血浆磷脂谱得到了显著改善。
