分子内烯烃碳氨化反应合成对映体富集的托烷衍生物。
Intramolecular alkene carboamination reactions for the synthesis of enantiomerically enriched tropane derivatives.
机构信息
Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109-1055, United States.
出版信息
Org Lett. 2011 Jun 3;13(11):2962-5. doi: 10.1021/ol201051q. Epub 2011 May 11.
Abstract
The synthesis of tropane derivatives via intramolecular Pd-catalyzed alkene difunctionalization reactions is described. Enantiopure N-aryl-γ-aminoalkenes bearing an aryl or alkenyl halide adjacent to the amino group were converted to benzo- or cycloalkenyl-fused tropane products in good yield and with no loss of enantiopurity.
摘要
描述了通过分子内 Pd 催化的烯烃双官能化反应合成托烷衍生物。邻氨基的手性 N-芳基-γ-氨基烯烃带有芳基或烯基卤化物，在氨基的相邻位置，通过该反应可以很好的产率及非对映选择性转化为苯并或环烯基稠合的托烷产物。
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