维生素 B12 与老年人。
Vitamin B12 and older adults.
机构信息
Division of Nutritional Sciences, Cornell University, Ithaca, New York 14850, USA.
出版信息
Curr Opin Clin Nutr Metab Care. 2010 Jan;13(1):24-7. doi: 10.1097/MCO.0b013e328333d157.
Abstract
PURPOSE OF REVIEW
To review the prevalence, causes and functional significance of vitamin B12 deficiency in vulnerable subpopulations including older adults and the developing embryo.
RECENT FINDINGS
It is becoming increasingly recognized that the susceptibility to vitamin B12 deficiency may change throughout the life cycle, with the developing embryo and older adults exhibiting elevated risk. Recent data implicate low vitamin B12 status as a risk factor for birth defects resulting from improper neural tube development. The potential for vitamin supplementation and/or food fortification to ameliorate the risk of deficiency in these subpopulations is discussed.
SUMMARY
The prevalence and impact of vitamin B12 deficiency varies throughout the life cycle, with older adults and potentially the developing embryo having the greatest risk and susceptibility. Additional research is needed to develop effective public health interventions that address the unique causes of this nutritional deficiency, which differ among at-risk subpopulations.
摘要
目的综述
审查易患人群（包括老年人和胚胎发育期）维生素 B12 缺乏症的流行率、病因和功能意义。
最新发现
人们越来越认识到，维生素 B12 缺乏症的易感性可能会在整个生命周期中发生变化，胚胎发育期和老年人的风险增加。最近的数据表明，维生素 B12 水平低是神经管发育异常导致出生缺陷的一个危险因素。讨论了在这些人群中补充维生素和/或食物强化以改善维生素 B12 缺乏症风险的可能性。
总结
维生素 B12 缺乏症的流行率和影响在整个生命周期中有所不同，老年人和胚胎发育期的人风险最大、最易感染。需要进一步研究以制定有效的公共卫生干预措施，解决不同高危人群之间存在的这种营养缺乏症的独特原因。
相似文献
1
Vitamin B12 and older adults.维生素 B12 与老年人。
Curr Opin Clin Nutr Metab Care. 2010 Jan;13(1):24-7. doi: 10.1097/MCO.0b013e328333d157.
2
Efficacy and safety of fortification and supplementation with vitamin B12: biochemical and physiological effects.维生素B12强化与补充的疗效和安全性：生化及生理效应
Food Nutr Bull. 2008 Jun;29(2 Suppl):S177-87. doi: 10.1177/15648265080292S121.
3
Vitamin B12 deficiency as a worldwide problem.维生素B12缺乏是一个全球性问题。
Annu Rev Nutr. 2004;24:299-326. doi: 10.1146/annurev.nutr.24.012003.132440.
4
Comparison of two modes of vitamin B12 supplementation on neuroconduction and cognitive function among older people living in Santiago, Chile: a cluster randomized controlled trial. a study protocol [ISRCTN 02694183].两种维生素 B12 补充模式对智利圣地亚哥老年人神经传导和认知功能影响的比较：一项整群随机对照试验。研究方案 [ISRCTN 02694183]。
Nutr J. 2011 Sep 27;10:100. doi: 10.1186/1475-2891-10-100.
5
Clinical chemistry of vitamin B12.维生素B12的临床化学
Adv Clin Chem. 1985;24:163-216. doi: 10.1016/s0065-2423(08)60273-5.
6
Chapter 30: historical aspects of the major neurological vitamin deficiency disorders: the water-soluble B vitamins.第30章：主要神经维生素缺乏症的历史概况：水溶性B族维生素
Handb Clin Neurol. 2010;95:445-76. doi: 10.1016/S0072-9752(08)02130-1.
7
Folate and vitamin B12: function and importance in cognitive development.叶酸与维生素B12：在认知发育中的功能及重要性
Nestle Nutr Inst Workshop Ser. 2012;70:161-71. doi: 10.1159/000337684. Epub 2012 Aug 31.
8
Long-term neurologic consequences of nutritional vitamin B12 deficiency in infants.婴儿营养性维生素B12缺乏的长期神经学后果。
J Pediatr. 1992 Nov;121(5 Pt 1):710-4. doi: 10.1016/s0022-3476(05)81897-9.
9
A high prevalence of biochemical evidence of vitamin B12 or folate deficiency does not translate into a comparable prevalence of anemia.维生素B12或叶酸缺乏的生化证据高发生率并不等同于贫血的相似发生率。
Food Nutr Bull. 2008 Jun;29(2 Suppl):S74-85. doi: 10.1177/15648265080292S111.
10
If high folic acid aggravates vitamin B12 deficiency what should be done about it?如果高剂量叶酸会加重维生素B12缺乏，对此应如何处理？
Nutr Rev. 2007 Oct;65(10):451-8. doi: 10.1111/j.1753-4887.2007.tb00270.x.
引用本文的文献
1
Status of Common Water-Soluble Vitamins in Medical Students: A Cross-Sectional Analysis with Implications for Targeted Nutritional Screening Programs.医学生常见水溶性维生素状况：一项对针对性营养筛查项目有启示的横断面分析
Nutrients. 2025 Sep 4;17(17):2862. doi: 10.3390/nu17172862.
2
Scoping review of micronutrient imbalances, clinical manifestations, and interventions.微量营养素失衡、临床表现及干预措施的范围综述
World J Methodol. 2025 Dec 20;15(4):107664. doi: 10.5662/wjm.v15.i4.107664.
3
Cancer progression through the lens of age-induced metabolic reprogramming.从年龄诱导的代谢重编程角度看癌症进展
Nat Rev Cancer. 2025 Jul 11. doi: 10.1038/s41568-025-00845-4.
4
Nutritional implications of alternative proteins: a commentary.替代蛋白质的营养影响：一篇评论
Public Health Nutr. 2025 Mar 17;28(1):e69. doi: 10.1017/S1368980025000242.
5
In vitro effect of vitaminB on embyro growth by induction of hypoxia in culture.维生素B在体外通过诱导培养环境中的缺氧对胚胎生长的影响。
Toxicol Res (Camb). 2024 Dec 9;13(6):tfae207. doi: 10.1093/toxres/tfae207. eCollection 2024 Dec.
6
Nutritional Supplements for Healthy Aging: A Critical Analysis Review.健康老龄化的营养补充剂：批判性分析综述
Am J Lifestyle Med. 2024 Apr 9;19(3):346-360. doi: 10.1177/15598276241244725. eCollection 2025 Mar-Apr.
7
Vitamin B12 status and the risk of developing sepsis in patients with bacterial infection: a prospective observational cohort study.维生素 B12 状况与细菌性感染患者发生脓毒症的风险：一项前瞻性观察性队列研究。
BMC Med. 2024 Aug 13;22(1):330. doi: 10.1186/s12916-024-03552-3.
8
Metformin-Induced Vitamin B12 Deficiency in Patients with Type 2 Diabetes: A Narrative Review with a Practical Approach for Screening, Diagnosing, and Managing Vitamin B12 Deficiency.2型糖尿病患者中二甲双胍诱导的维生素B12缺乏：一篇关于维生素B12缺乏筛查、诊断及管理实用方法的叙述性综述
Korean J Fam Med. 2024 Jul;45(4):189-198. doi: 10.4082/kjfm.24.0090. Epub 2024 Jul 18.
9
Nutritional Challenges in Nursing Homes: Pilot Study on Macronutrient Intake and Status of Vitamins D and B12.养老院的营养挑战：宏量营养素摄入和维生素 D 和 B12 状况的初步研究。
Nutrients. 2024 May 15;16(10):1495. doi: 10.3390/nu16101495.
10
An Update on Drug-Nutrient Interactions and Dental Decay in Older Adults.老年人药物-营养素相互作用与龋齿的最新研究进展。
Nutrients. 2023 Nov 23;15(23):4900. doi: 10.3390/nu15234900.
本文引用的文献
1
Homocysteine, folate and vitamin B12 in neuropsychiatric diseases: review and treatment recommendations.神经精神疾病中的同型半胱氨酸、叶酸和维生素B12：综述与治疗建议
Expert Rev Neurother. 2009 Sep;9(9):1393-412. doi: 10.1586/ern.09.75.
2
Homocysteine and holo-transcobalamin and the risk of dementia and Alzheimers disease: a prospective study.同型半胱氨酸与全转钴胺素及痴呆症和阿尔茨海默病风险：一项前瞻性研究。
Eur J Neurol. 2009 Jul;16(7):808-13. doi: 10.1111/j.1468-1331.2009.02590.x. Epub 2009 Apr 21.
3
Studies of biomarker responses to intervention with vitamin B-12: a systematic review of randomized controlled trials.维生素B-12干预生物标志物反应的研究：随机对照试验的系统评价
Am J Clin Nutr. 2009 Jun;89(6):1981S-1996S. doi: 10.3945/ajcn.2009.27230C. Epub 2009 Apr 29.
4
Folate, related B vitamins, and homocysteine in childhood and adolescence: potential implications for disease risk in later life.儿童和青少年时期的叶酸、相关B族维生素与同型半胱氨酸：对晚年疾病风险的潜在影响。
Pediatrics. 2009 Feb;123(2):627-35. doi: 10.1542/peds.2008-1049.
5
Is it time for vitamin B-12 fortification? What are the questions?是时候进行维生素B-12强化了吗？有哪些问题呢？
Am J Clin Nutr. 2009 Feb;89(2):712S-6S. doi: 10.3945/ajcn.2008.26947E. Epub 2009 Jan 13.
6
Vitamin B-12 and neural tube defects: the Canadian experience.维生素B-12与神经管缺陷：加拿大的经验
Am J Clin Nutr. 2009 Feb;89(2):697S-701S. doi: 10.3945/ajcn.2008.26947B. Epub 2008 Dec 30.
7
How common is vitamin B-12 deficiency?维生素B12缺乏症有多常见？
Am J Clin Nutr. 2009 Feb;89(2):693S-6S. doi: 10.3945/ajcn.2008.26947A. Epub 2008 Dec 30.
8
Update of nutrient-deficiency anemia in elderly patients.老年患者营养缺乏性贫血的最新进展。
Eur J Intern Med. 2008 Nov;19(7):488-93. doi: 10.1016/j.ejim.2008.01.016. Epub 2008 Mar 14.
9
An update on cobalamin deficiency in adults.成人维生素B12缺乏症的最新进展。
QJM. 2009 Jan;102(1):17-28. doi: 10.1093/qjmed/hcn138. Epub 2008 Nov 5.
10
Nutritional anemias and the elderly.营养性贫血与老年人。
Semin Hematol. 2008 Oct;45(4):225-34. doi: 10.1053/j.seminhematol.2008.07.009.
Zotero 插件