Makrilia Nektaria, Kollias Anastasios, Manolopoulos Leonidas, Syrigos Kostas
Oncology Unit, 3rd Department of Medicine, Sotiria General Hospital, Athens School of Medicine, Greece.
Cancer Invest. 2009 Dec;27(10):1023-37. doi: 10.3109/07357900902769749.
There is a growing body of evidence suggesting that alterations in the adhesion properties of neoplastic cells endow them with an invasive and migratory phenotype. Indeed, changes in the expression or function of cell adhesion molecules have been implicated in all steps of tumor progression, including detachment of tumor cells from the primary site, intravasation into the blood stream, extravasation into distant target organs, and formation of the secondary lesions. This review presents recent data regarding the role of cell adhesion molecules in tumor development and progress with concern to their clinical exploitation as potential biomarkers in neoplastic diseases.
越来越多的证据表明，肿瘤细胞黏附特性的改变使其具有侵袭和迁移表型。事实上，细胞黏附分子表达或功能的变化与肿瘤进展的各个步骤都有关联，包括肿瘤细胞从原发部位脱离、侵入血流、渗出到远处靶器官以及形成继发性病变。本综述介绍了有关细胞黏附分子在肿瘤发生和进展中的作用的最新数据，并关注其作为肿瘤疾病潜在生物标志物的临床应用。
