Rivas A L, Fabricant J
Department of Avian and Aquatic Animal Medicine, New York State College of Veterinary Medicine, Cornell University, Ithaca 14853.
Avian Dis. 1988 Jan-Mar;32(1):1-8.
The effect of infection by various strains of Marek's disease virus (MDV) on the immune function of 3-week-old chickens was examined. MDV strains of low (CU-2, RB-7) and high (RB-3, MD-5, and MD-11) pathogenicity were compared with prototype JM-10 strain of moderate pathogenicity. Mortality, whole body weight, relative weights of lymphoid organs, histopathology, humoral antibody responses to thymus-dependent and -independent antigens, and in vitro lymphocyte responses to mitogen stimulation were investigated at 1, 2, and 3 weeks postinfection. MDV strains of high pathogenicity significantly depressed responses at 3 weeks postinfection, seeming to indicate the ability of these viruses to induce severe immunodepression. However, the fact that the moderately pathogenic and even some of the low-pathogenicity strains induced immunodepression suggests that other viral mechanisms are also important in its determination.
研究了不同毒株的马立克氏病病毒（MDV）感染对3周龄雏鸡免疫功能的影响。将低致病性（CU - 2、RB - 7）和高致病性（RB - 3、MD - 5和MD - 11）的MDV毒株与中等致病性的原型JM - 10毒株进行比较。在感染后1周、2周和3周，对死亡率、全身重量、淋巴器官相对重量、组织病理学、对胸腺依赖性和非胸腺依赖性抗原的体液抗体反应以及体外淋巴细胞对丝裂原刺激的反应进行了研究。高致病性MDV毒株在感染后3周显著抑制反应，这似乎表明这些病毒具有诱导严重免疫抑制的能力。然而，中等致病性甚至一些低致病性毒株也诱导免疫抑制这一事实表明，其他病毒机制在其发生过程中也很重要。
