Department of Neurology and Ophthalmology, University of Kentucky College of Medicine, KY Clinic L-445, Lexington, KY 40536, USA.
Graefes Arch Clin Exp Ophthalmol. 2010 Feb;248(2):283-7. doi: 10.1007/s00417-009-1227-y. Epub 2009 Nov 15.
Anti-tumor necrosis factor alpha (TNF alpha) agents have been increasingly used to treat patients with Crohn's disease, psoriatic arthritis, rheumatoid arthritis, ankylosing spondylitis, and persistent uveitis. We describe a 68-year-old man with Crohn's esophagitis who developed a possible bilateral toxic anterior optic neuropathy during infliximab infusion.
This is an observational case report, with review of the PubMed literature from 1977 to present.
This 68-year-old man with a 2-year history of Crohn's esophagitis developed acute bilateral visual loss during his third infliximab infusion. His clinical features and laboratory tests were characteristic for a bilateral anterior optic neuropathy. Only three cases of possible infliximab-associated anterior optic neuropathy have been reported in the literature to date.
It is important to consider the possibility of anterior optic neuropathy, in addition to retrobulbar optic neuritis, in patients who experience sudden-onset visual loss while being treated with infliximab.
抗肿瘤坏死因子 α（TNF-α）药物已被越来越多地用于治疗克罗恩病、银屑病关节炎、类风湿关节炎、强直性脊柱炎和持续性葡萄膜炎患者。我们描述了一例 68 岁男性克罗恩病食管炎患者，在接受英夫利昔单抗输注期间发生双侧中毒性前部视神经病变的可能情况。
这是一项观察性病例报告，并对 1977 年至目前的 PubMed 文献进行了回顾。
这位 68 岁男性患有 2 年的克罗恩病食管炎病史，在第三次英夫利昔单抗输注期间出现急性双侧视力丧失。他的临床特征和实验室检查均符合双侧前部视神经病变。迄今为止，文献中仅报道了三例可能与英夫利昔单抗相关的前部视神经病变。
在使用英夫利昔单抗治疗的患者出现突发性视力丧失时，除了球后视神经炎外，还应考虑前部视神经病变的可能性。
