Munakata Shun, Arakawa Chikako, Kohira Ryutaro, Fujita Yukihiko, Fuchigami Tatsuo, Mugishima Hideo
Department of Pediatrics, Nihon University School of Medicine, Tokyo, Japan.
Brain Dev. 2010 Sep;32(8):691-4. doi: 10.1016/j.braindev.2009.09.024. Epub 2009 Nov 14.
A five year old girl was admitted to the hospital for evaluation of intermittent ataxia. She had undergone serial resections of the small intestine after birth, resulting in short bowel syndrome. Lactomin was prescribed for watery diarrhea at twice the regular dose 2 weeks before the onset of neurologic symptoms. D-lactic acidosis was diagnosed on the basis of a plasma D-lactate level of 5.537 mmol/l. Lactomin was discontinued, and she was treated with sodium bicarbonate and oral antibiotics. The probiotics the patient had taken were likely the cause of D-lactic acidosis and should therefore be avoided in patients with short bowel syndrome.
一名五岁女孩因间歇性共济失调入院评估。她出生后接受了多次小肠切除术，导致短肠综合征。在出现神经症状前两周，给予拉克托敏治疗水样腹泻，剂量为常规剂量的两倍。根据血浆D-乳酸水平5.537 mmol/l诊断为D-乳酸酸中毒。停用拉克托敏，并用碳酸氢钠和口服抗生素治疗。该患者服用的益生菌可能是D-乳酸酸中毒的原因，因此短肠综合征患者应避免使用。
