用于再生医学中生物分子控释的聚乙二醇水凝胶
PEG hydrogels for the controlled release of biomolecules in regenerative medicine.
作者信息
Lin Chien-Chi, Anseth Kristi S
机构信息
Department of Chemical and Biological Engineering, University of Colorado, Boulder, Colorado, 80309, USA.
出版信息
Pharm Res. 2009 Mar;26(3):631-43. doi: 10.1007/s11095-008-9801-2. Epub 2008 Dec 18.
Abstract
Polyethylene glycol (PEG) hydrogels are widely used in a variety of biomedical applications, including matrices for controlled release of biomolecules and scaffolds for regenerative medicine. The design, fabrication, and characterization of PEG hydrogels rely on the understanding of fundamental gelation kinetics as well as the purpose of the application. This review article will focus on different polymerization mechanisms of PEG-based hydrogels and the importance of these biocompatible hydrogels in regenerative medicine applications. Furthermore, the design criteria that are important in maintaining the availability and stability of the biomolecules as well as the mechanisms for loading of biomolecules within PEG hydrogels will also be discussed. Finally, we overview and provide a perspective on some of the emerging novel design and applications of PEG hydrogel systems, including the spatiotemporal-controlled delivery of biomolecules, hybrid hydrogels, and PEG hydrogels designed for controlled stem cell differentiation.
摘要
聚乙二醇（PEG）水凝胶广泛应用于各种生物医学领域，包括用于生物分子控释的基质和用于再生医学的支架。PEG水凝胶的设计、制备和表征依赖于对基本凝胶化动力学的理解以及应用目的。这篇综述文章将聚焦于基于PEG的水凝胶的不同聚合机制以及这些生物相容性水凝胶在再生医学应用中的重要性。此外，还将讨论在维持生物分子的可用性和稳定性方面重要的设计标准以及生物分子在PEG水凝胶中的负载机制。最后，我们概述并展望了PEG水凝胶系统的一些新兴的新颖设计和应用，包括生物分子的时空控制递送、混合水凝胶以及为控制干细胞分化而设计的PEG水凝胶。
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