Key Laboratory of Systematic Mycology & Lichenology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100190, People's Republic of China.
J Nat Prod. 2009 Dec;72(12):2115-9. doi: 10.1021/np900654a.
New diketopiperazines, epicoccins E-H (1-4) and diphenylalazines A (5) and B (6), have been isolated from the solid-substrate fermentation culture of the Cordyceps-colonizing fungus Epicoccum nigrum. The structures of 1-6 were determined primarily by NMR experiments, and the structure of 1 was confirmed by X-ray crystallography. The absolute configurations of 3 and 5 were assigned using the modified Mosher (3) and Marfey's (5) methods, respectively. Compounds 3-5 showed inhibitory effects on HIV-1 replication in C8166 cells.
新的二酮哌嗪类化合物，epicoccins E-H（1-4）和二苯并嗪 A（5）和 B（6），已从虫草菌寄生真菌黑曲霉的固体基质发酵培养物中分离出来。1-6 的结构主要通过 NMR 实验确定，1 的结构通过 X 射线晶体学确定。使用改进的 Mosher（3）和 Marfey's（5）方法分别确定了 3 和 5 的绝对构型。化合物 3-5 对 C8166 细胞中的 HIV-1 复制具有抑制作用。
