Xiao Wei-Lie, Gong Yan-Qing, Wang Rui-Rui, Weng Zhi-Ying, Luo Xiao, Li Xiao-Nian, Yang Guang-Yu, He Fei, Pu Jian-Xin, Yang Liu-Meng, Zheng Yong-Tang, Lu Yang, Sun Han-Dong
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan, People's Republic of China.
J Nat Prod. 2009 Sep;72(9):1678-81. doi: 10.1021/np900292e.
Three new nortriterpenoids, schigrandilactones A-C (1-3), along with eight known compounds, were isolated from an organic solvent extract of Schisandra grandiflora. Compounds 1 and 2 feature a spirocyclic moiety in their structures, and compound 3 was characterized with a new oxygenated pattern. The relative configurations of 1 and 3 were determined through single-crystal X-ray experiments. In addition, compounds 1 and 2 displayed cytotoxic activity against two human cancer cell lines, and compound 3 showed anti-HIV-1 inhibition in infected C8166 cells.
从大花五味子的有机溶剂提取物中分离出三种新的三萜类化合物，五味子内酯A-C（1-3），以及八种已知化合物。化合物1和2的结构中具有螺环部分，化合物3具有新的氧化模式。通过单晶X射线实验确定了1和3的相对构型。此外，化合物1和2对两种人类癌细胞系显示出细胞毒性活性，化合物3在感染的C8166细胞中表现出抗HIV-1抑制作用。
