Eutheria Foundation, Cross Plains, Wisconsin 53528, USA.
Reproduction. 2010 Feb;139(2):453-63. doi: 10.1530/REP-09-0363. Epub 2009 Nov 17.
Colour-Doppler ultrasonography was used to study the spatial relationship between vascular perfusion in the middle of each uterine horn and the reported location of the embryo proper and expanding conceptus using endometrial vascularity scores 1-4 (nil-maximal). Vascularity increased in both uterine horns between days 14 and 18 (day 0=ovulation) in nonpregnant heifers (n=6) but not in pregnant heifers (n=11). The increase was temporally associated with decreasing plasma progesterone and increasing oestradiol. In pregnant heifers, a transient increase in endometrial vascularity in the ipsilateral horn (horn with embryo) was not detected before day 18, despite a reported transient increase in blood flow in the ipsilateral uterine artery between days 13 and 17. Endometrial vascularity in the ipsilateral horn first increased (P<0.05) between days 18 and 20. Day 20 is the reported day of adhesiveness between chorion and uterus. An increase (P<0.05) in the contralateral horn between days 18 and 22 was slight, but a greater increase occurred after day 32. Day 32 is the reported day of entry of the allantochorion into the contralateral horn. By day 42, scores were similar between the two horns, and the allantochorion reportedly fills both horns. On days 42-60, at a time when placentomes apparently are limited to the ipsilateral horn, vascularity remained elevated in the ipsilateral horn but decreased in the contralateral horn. Results support the hypothesis that vascular perfusion in each uterine horn during early pregnancy is mediated by direct contact between conceptus and uterus.
彩色多普勒超声用于研究每个子宫角中部血管灌注与胚胎本身和扩张胚胎的报告位置之间的空间关系，使用子宫内膜血管评分 1-4（无-最大）。在非妊娠小母牛（n=6）中，在排卵后 14 至 18 天（第 0 天），两个子宫角的血管生成都增加，但在妊娠小母牛（n=11）中没有增加。这种增加与血浆孕酮的减少和雌二醇的增加有关。在妊娠小母牛中，尽管在第 13 至 17 天同侧子宫动脉血流报告有短暂增加，但在第 18 天之前未检测到同侧角（有胚胎的角）子宫内膜血管生成的短暂增加。同侧角的子宫内膜血管生成首先在第 18 至 20 天增加（P<0.05）。第 20 天是绒毛膜和子宫之间报道的黏附日。第 18 至 22 天对侧角的增加（P<0.05）较小，但在第 32 天后增加更大。第 32 天是报道的尿囊绒毛膜进入对侧角的日子。到第 42 天，两个角的评分相似，据报道尿囊绒毛膜充满了两个角。在第 42-60 天，当胎盘瘤显然局限于同侧角时，同侧角的血管生成仍然升高，但对侧角的血管生成下降。结果支持这样的假设，即在妊娠早期每个子宫角的血管灌注是由胚胎与子宫的直接接触介导的。
