Department of Chemistry, Himachal Pradesh University, Shimla, 171005, India.
J Mater Sci Mater Med. 2010 Feb;21(2):717-24. doi: 10.1007/s10856-009-3932-9. Epub 2009 Nov 18.
A series of new bioactive polymers with pendant choline analogous group was prepared by anion exchange reaction direct at the quaternary nitrogen of the polycation. Poly(4-vinyl 2-hydroxyethyl pyridinium) chloride was prepared in situ by simultaneous polymerization and quaternization of 4-vinyl pyridine with 2-chloroethanol that also acts as catalyst. The counter anion (Cl(-)) of the polycation was exchanged by anion exchange reaction with Br(-), (-)OH, (-)SH, NO(3) (-), BF(4) (-) or CF(3)COO(-). Evidence of anion exchange was obtained by the characterization of the resultant polymers. The nature of the counter anion has profound effect on their properties including strong anion-dependent anti-microbial activity against bacteria and fungus. Polymer containing (-)OH was observed to be the most potent anti-microbial agent with the lowest minimum inhibitory concentration against both the classes of microbes studied.
一系列具有侧链胆碱类似物的新型生物活性聚合物是通过阴离子交换反应直接在聚阳离子的季氮原子上制备的。聚（4-乙烯基 2-羟乙基吡啶𬭩）氯化物是通过 4-乙烯基吡啶与 2-氯乙醇的同时聚合和季铵化原位制备的，2-氯乙醇也用作催化剂。聚阳离子的抗衡阴离子（Cl(-)）通过阴离子交换反应与 Br(-)、(-)OH、(-)SH、NO(3) (-)、BF(4) (-)或 CF(3)COO(-)交换。通过对所得聚合物的表征获得了阴离子交换的证据。抗衡阴离子的性质对其性质具有深远的影响，包括对细菌和真菌的强烈阴离子依赖性抗微生物活性。含有（-）OH 的聚合物被观察到是最有效的抗微生物剂，对研究的两类微生物的最低抑菌浓度最低。
