Department of Chemistry, Portland State University, Portland, OR 97207, USA.
Curr Opin Chem Biol. 2010 Feb;14(1):64-70. doi: 10.1016/j.cbpa.2009.10.022. Epub 2009 Nov 18.
Fluorescent dyes based on small organic molecules that function in the near infrared (NIR) region are of great current interest in chemical biology. They allow for imaging with minimal autofluorescence from biological samples, reduced light scattering, and high tissue penetration. Herein, examples of ongoing NIR fluorophore design strategies as well as their properties and anticipated applications relevant to the bioimaging are presented.
基于小分子的荧光染料在近红外（NIR）区域具有重要的应用价值，目前在化学生物学领域受到广泛关注。这些染料可以实现最小化生物样本的自发荧光、减少光散射和提高组织穿透深度的成像。本文介绍了当前 NIR 荧光团设计策略的实例，以及它们的性质和预期在生物成像方面的应用。
