Okulov V B, Anisimov V N, Azarova M A
Exp Pathol (Jena). 1978;15(3):178-81. doi: 10.1016/s0014-4908(78)80053-2.
The effect of chalone-containing ethanol extract of rat skin (CCE) on the growth in mice of transplanted uterine cervix and skin carcinomas, hepatoma-22a, sarcoma-180 and leukemia L-1210 was studied. When CCE is added to the suspension of tumour cells (10 mg CCE/100 mg tumour tissue/ml saline) the most obvious retention of tumour growth is observed on squamous-cell carcinoma of uterine cervix (72.6%; p less than 0.01). The effect of CCE on the growth of other transplanted tumours, including the skin carcinoma, is not significant. As compared to the uterine cervix carcinoma, the skin carcinoma lacked its primary squamous-cell structure during the tumour progression. The possibility of applicative use of chalones for cancer control is discussed.
研究了大鼠皮肤含抑素乙醇提取物（CCE）对移植于小鼠的子宫颈癌、皮肤癌、肝癌-22a、肉瘤-180和白血病L-1210生长的影响。当将CCE添加到肿瘤细胞悬液中（10毫克CCE/100毫克肿瘤组织/毫升生理盐水）时，在子宫颈鳞状细胞癌上观察到最明显的肿瘤生长抑制（72.6%；p<0.01）。CCE对包括皮肤癌在内的其他移植肿瘤生长的影响不显著。与子宫颈癌相比，皮肤癌在肿瘤进展过程中缺乏其原发性鳞状细胞结构。讨论了抑素在癌症控制中的应用可能性。
