Greisman S G, Thayaparan R S, Godwin T A, Lockshin M D
Department of Medicine, St Luke's-Roosevelt Hospital Center, New York, NY 10019.
Arch Intern Med. 1991 Feb;151(2):389-92.
Patients with systemic lupus erythematosus and with antiphospholipid antibody are subject to sudden occlusion of multiple blood vessels. We describe two patients with systemic lupus erythematosus with acute, catastrophic, widespread non-inflammatory visceral vascular occlusions associated with high-titer antiphospholipid antibody. The histopathologic features clearly distinguished these patients from classic systemic lupus erythematosus vasculitis. We further suggest that, based on a probable pathogenesis related to the presence of antiphospholipid antibody, and based on the non-inflammatory vascular occlusion, steroids and other immunosuppressive medications are of limited value. Plasmapheresis along with anticoagulant therapy should be considered.
患有系统性红斑狼疮和抗磷脂抗体的患者易发生多血管突然闭塞。我们描述了两名患有系统性红斑狼疮的患者，他们出现了与高滴度抗磷脂抗体相关的急性、灾难性、广泛的非炎症性内脏血管闭塞。组织病理学特征将这些患者与经典的系统性红斑狼疮血管炎明确区分开来。我们进一步认为，基于与抗磷脂抗体存在相关的可能发病机制，以及基于非炎症性血管闭塞，类固醇和其他免疫抑制药物的价值有限。应考虑进行血浆置换并联合抗凝治疗。
