Department of Urology, The Catholic University of Korea, College of Medicine, Seoul, Korea.
Int J Urol. 2010 Jan;17(1):55-61. doi: 10.1111/j.1442-2042.2009.02425.x. Epub 2009 Nov 23.
To compare the mid-term oncological outcome of laparoscopic radical cystectomy (LRC) with those of open radical cystectomy (ORC).
From June 2003 to February 2008, 36 LRCs were carried out at our institute for the treatment of bladder cancer. Clinical and oncological data were retrospectively analyzed. A match-pair comparison with an historical series of 34 patients who were submitted to ORC between 1996 and 2003 was carried out.
Median follow-up of the LRC group was 21 months (3-56 months). Pathological stage or grade was similar in the two groups. There was no significant difference between the LRC and ORC groups in terms of 3-year overall (64.2% vs 72.6%, respectively; P = 0.682), cancer-specific (73.0% vs 75.3%, respectively; P = 0.951), and recurrence-free survival (70.5% vs 72.5%, respectively; P = 0.715) rates. In a subgroup analysis according to stage, there was also no significant difference in the 3-year disease-specific survival after LRC or ORC for organ-confined (pT1 and pT2; 85.7% vs 83.9%, respectively; P = 0.256) or extravesical disease (pT3 and pT4; 73.3% vs 63.8%, respectively; P = 0.825).
These findings suggest that LRC provides mid-term oncological outcomes similar to those of ORC in the management of bladder cancer.
比较腹腔镜根治性膀胱切除术（LRC）与开放性根治性膀胱切除术（ORC）的中期肿瘤学结果。
2003 年 6 月至 2008 年 2 月，本研究所对 36 例膀胱癌患者进行了 LRC 治疗。回顾性分析了临床和肿瘤学数据。与 1996 年至 2003 年间接受 ORC 治疗的 34 例患者的历史系列进行了配对比较。
LRC 组的中位随访时间为 21 个月（3-56 个月）。两组的病理分期或分级相似。在 3 年总生存率（分别为 64.2%和 72.6%；P=0.682）、癌症特异性生存率（分别为 73.0%和 75.3%；P=0.951）和无复发生存率（分别为 70.5%和 72.5%；P=0.715）方面，LRC 组与 ORC 组之间无显著差异。根据分期进行亚组分析，在局限性疾病（pT1 和 pT2；分别为 85.7%和 83.9%；P=0.256）或非膀胱疾病（pT3 和 pT4；分别为 73.3%和 63.8%；P=0.825）中，LRC 或 ORC 后的 3 年疾病特异性生存率也无显著差异。
这些发现表明，LRC 为膀胱癌的治疗提供了与 ORC 相似的中期肿瘤学结果。
