痛风性关节炎中的细胞内固有免疫：NALP3 炎性小体的作用。
Intracellular innate immunity in gouty arthritis: role of NALP3 inflammasome.
机构信息
Department of Medicine, VA Medical Center, University of California, San Diego, CA, USA.
出版信息
Immunol Cell Biol. 2010 Jan;88(1):20-3. doi: 10.1038/icb.2009.93. Epub 2009 Nov 24.
Abstract
Gout is an inflammatory disease caused by the deposition of monosodium urate (MSU) crystals in the joint. Recent studies have significantly advanced our knowledge on the understanding of mechanisms underlying MSU crystal-induced inflammation. MSU crystals act as a 'danger signal' that can be recognized by pattern recognition receptors both at cell surface and cytoplasm, indicating the importance of innate immunity in gout. This review focuses on the critical role of intracellular NALP3 inflammasome in MSU crystal-induced inflammation.
摘要
痛风是一种炎症性疾病，由单钠尿酸盐（MSU）晶体在关节中的沉积引起。最近的研究极大地提高了我们对理解 MSU 晶体诱导炎症机制的认识。MSU 晶体作为一种“危险信号”，可以被细胞表面和细胞质中的模式识别受体识别，这表明先天免疫在痛风中起着重要作用。本综述重点介绍了细胞内 NALP3 炎性小体在 MSU 晶体诱导炎症中的关键作用。
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