Takada Kensuke, Jameson Stephen C
Center for Immunology, Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA.
Nat Rev Immunol. 2009 Dec;9(12):823-32. doi: 10.1038/nri2657.
The peripheral naive T cell pool is fairly stable in number, diversity and functional competence in the absence of vigorous immune responses. However, this apparent tranquility is not an intrinsic property of T cells but involves continuous tuning of the T cell pool composition by homeostatic signals. In the past decade, studies have revealed that naive T cells rely on combinatorial signals from self-peptide-MHC complexes and interleukin-7 for their physical and functional maintenance. Competition for these factors dictates T cell 'space'. In addition, recent studies show that these and other homeostatic factors are offered to T cells on stromal cell networks, which also serve to guide T cell trafficking in secondary lymphoid organs. Such findings suggest the importance of 'place' in the perception and integration of homeostatic cues for the maintenance and functional tuning of the naive T cell pool.
在没有强烈免疫反应的情况下，外周幼稚T细胞库在数量、多样性和功能能力方面相当稳定。然而，这种表面上的平静并非T细胞的固有特性，而是涉及通过稳态信号对T细胞库组成进行持续调节。在过去十年中，研究表明幼稚T细胞依靠来自自身肽-MHC复合物和白细胞介素-7的组合信号来维持其物理和功能状态。对这些因子的竞争决定了T细胞的“空间”。此外，最近的研究表明，这些及其他稳态因子是由基质细胞网络提供给T细胞的，基质细胞网络还在次级淋巴器官中引导T细胞的迁移。这些发现表明“位置”对于幼稚T细胞库的维持和功能调节在感知和整合稳态信号方面具有重要意义。
