Erbilen Enver, Yazici Selma, Ozhan Hakan, Bulur Serkan, Ordu Serkan, Yazici Mehmet
Department of Cardiology, Düzce University, Düzce, Turkey.
Circ J. 2007 Jul;71(7):1095-8. doi: 10.1253/circj.71.1095.
The present study aimed to investigate the association between low bone mass (LBM) and coronary artery disease (CAD) in male patients.
The data for 47 men who were screened for osteopenia and osteoporosis with dual energy X-ray absorptiometry and then underwent coronary angiography between February 2005 and May 2006 were retrospectively analyzed. Bone mineral density of the femur neck was stratified as normal (T score >-1.0 SD) or low (T score <-1.0 SD) and CAD was defined as > or = 50% occlusion in at least 1 major coronary artery. Thirty-two patients were found to have angiographically significant CAD. Patients in the LBM group had a significantly higher incidence of CAD. Low bone mass was significantly and positively correlated with the Gensini scores of the patients (r=0.6037, p<0.0001) and was found to be an independent predictor of CAD in multivariate logistic regression analysis (odds ratio: 5.4 [95% confidence interval 1.66 and 17.49]; p=0.0049). Repeated statistical analyses with the acceptance of CAD as coronary artery stenosis >75% confirmed the same results.
Low bone mass was significantly associated with angiographically documented CAD in males.
本研究旨在调查男性患者低骨量（LBM）与冠状动脉疾病（CAD）之间的关联。
回顾性分析了2005年2月至2006年5月期间47名男性患者的数据，这些患者先用双能X线吸收法筛查骨质减少和骨质疏松，然后接受冠状动脉造影。股骨颈骨密度分为正常（T值＞-1.0标准差）或低（T值＜-1.0标准差），CAD定义为至少1条主要冠状动脉闭塞≥50%。32例患者被发现有血管造影显示的显著CAD。LBM组患者CAD发生率显著更高。低骨量与患者的Gensini评分显著正相关（r = 0.6037，p ＜0.0001），并且在多变量逻辑回归分析中被发现是CAD的独立预测因子（比值比：5.4 [95%置信区间1.66和17.49]；p = 0.0049）。将CAD接受为冠状动脉狭窄＞75%进行重复统计分析证实了相同结果。
男性患者中，低骨量与血管造影记录的CAD显著相关。
