†Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, Oregon 97331-3507, United States.
‡Indonesian Center for Biodiversity and Biotechnology, ICBB-Complex, Jl. Cilubang Nagrak No. 62, Situgede, Bogor 16115, Indonesia.
Org Lett. 2015 May 15;17(10):2526-9. doi: 10.1021/acs.orglett.5b01055. Epub 2015 May 6.
Two new apoptolidins, 2'-O-succinyl-apoptolidin A (11) and 3'-O-succinyl-apoptolidin A (12), were isolated from the culture broth of an Indonesian Amycolatopsis sp. ICBB 8242. These compounds inhibit the proliferation and viability of human H292 and HeLa cells. However, in contrast to apoptolidin A (1), they do not inhibit cellular respiration in H292 cells. It is proposed that apoptolidins are produced and secreted in their succinylated forms and 1 is the hydrolysis product of 11 and 12.
两个新的凋亡菌素，2'-O-琥珀酰凋亡菌素 A（11）和 3'-O-琥珀酰凋亡菌素 A（12），从印度尼西亚 Amycolatopsis sp. ICBB 8242 的发酵液中分离得到。这些化合物抑制人 H292 和 HeLa 细胞的增殖和活力。然而，与凋亡菌素 A（1）不同，它们不抑制 H292 细胞中的细胞呼吸。据推测，凋亡菌素以它们的琥珀酰化形式产生和分泌，1 是 11 和 12 的水解产物。
