Department of Pediatrics, University of California, 521 Parnassus Avenue, C215, Box 0663, San Francisco, CA 94143, USA.
Clin Perinatol. 2009 Dec;36(4):859-80, vii. doi: 10.1016/j.clp.2009.07.013.
Neonatal brain injury is an important cause of death and disability, with pathways of oxidant stress, inflammation, and excitotoxicity that lead to damage that progresses over a long period of time. Therapies have classically targeted individual pathways during early phases of injury, but more recent therapies such as growth factors may also enhance cell proliferation, differentiation, and migration over time. More recent evidence suggests combined therapy may optimize repair, decreasing cell injury while increasing newly born cells.
新生儿脑损伤是死亡和残疾的重要原因，其氧化应激、炎症和兴奋毒性等途径导致损伤在很长一段时间内逐渐发展。治疗方法经典地针对损伤早期的单个途径，但最近的治疗方法，如生长因子，也可能随着时间的推移增强细胞增殖、分化和迁移。最近的证据表明，联合治疗可能会优化修复，减少细胞损伤，同时增加新产生的细胞。
