Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai, PR China.
Fitoterapia. 2010 Jul;81(5):375-80. doi: 10.1016/j.fitote.2009.11.004. Epub 2009 Nov 27.
Two new oleanolic acid saponins, namely celosin C (1) and celosin D (2), were isolated from the ethanol extract of Semen celosiae. Their structures were identified as celosin C (1) and celosin D (2) by spectroscopic and chemical analyses. The hepatoprotective activity of 1 and 2 with oral dose 1.0, 2.0 and 4.0 mg/kg, respectively, were investigated by carbon tetrachloride (CCl(4))-induced hepatotoxicity in mice. The results indicate that they have significant hepatoprotective effects (p<0.01).
从苍耳子的乙醇提取物中分离得到两个新的齐墩果酸皂苷，分别命名为苍耳子皂苷 C（1）和苍耳子皂苷 D（2）。通过光谱和化学分析鉴定它们的结构分别为苍耳子皂苷 C（1）和苍耳子皂苷 D（2）。以 1.0、2.0 和 4.0mg/kg 的口服剂量，分别对化合物 1 和 2 进行了四氯化碳（CCl(4))诱导的小鼠肝损伤的保肝活性研究。结果表明，它们具有显著的保肝作用（p<0.01）。
