Pharmacognosy Department, School of Pharmacy, Second Military Medical University, Shanghai 200433, P.R. China.
Nat Prod Res. 2011 Apr;25(8):772-80. doi: 10.1080/14786410902833948. Epub 2010 Mar 17.
Two new oleanolic acid saponins, namely celosin A (1) and celosin B (2), together with six known compounds, stigmasterol, β-sitosterol, β-daucosterol, hexacosoic acid, palmitic acid and stearic acid, were isolated from the ethanolic extract of Semen celosiae. The structures of celosin A (1) and celosin B (2) were determined by spectral analysis (including 1D- and 2D-NMR). The hepatoprotective activity of 1 and 2 with oral doses 1.0, 2.0 and 4.0 mg kg⁻¹ were investigated by carbon tetrachloride CCl₄-induced hepatotoxicity in mice. The results indicate that they have significant hepatoprotective effects, and that these hepatoprotective effects may be due to the antioxidant capability.
从苍耳子的乙醇提取物中分离得到两种新的齐墩果酸皂苷，即苍耳子皂苷 A（1）和苍耳子皂苷 B（2），以及六种已知化合物，豆甾醇、β-谷甾醇、β-胡萝卜苷、十六酸、棕榈酸和硬脂酸。通过光谱分析（包括 1D 和 2D-NMR）确定了苍耳子皂苷 A（1）和苍耳子皂苷 B（2）的结构。通过四氯化碳 CCl₄诱导的小鼠肝损伤，研究了化合物 1 和 2 的口服剂量为 1.0、2.0 和 4.0 mg kg⁻¹的保肝活性。结果表明，它们具有显著的保肝作用，这些保肝作用可能归因于抗氧化能力。
