Branch Hospital in Fengxian of Shanghai No 6 People's Hospital, 9588 NanFeng Road, Shanghai 201400, PR China.
Fitoterapia. 2011 Jun;82(4):591-4. doi: 10.1016/j.fitote.2011.01.007. Epub 2011 Jan 22.
A new triterpenoid saponin, named semenoside A (1), was isolated from Semen Celosia cristatae. Its structure was elucidated on the basis of 1D, 2D NMR, HR-FAB-MS and ESI-MS techniques, and physicochemical properties. The hepatoprotective activity of semenoside A with an oral dose of 1.0, 2.0 and 4.0mg/kg, respectively, were investigated by carbon tetrachloride (CCl(4))-induced hepatotoxicity in mice. The results indicated that it had significant hepatoprotective effects (p < 0.01).
从鸡冠花种子中分离得到一个新的三萜皂苷，命名为鸡冠花苷 A（1）。其结构通过 1D、2D NMR、HR-FAB-MS 和 ESI-MS 技术以及理化性质进行了阐明。通过四氯化碳（CCl（4））诱导的小鼠肝损伤模型，研究了鸡冠花苷 A 以 1.0、2.0 和 4.0mg/kg 的口服剂量的保肝活性。结果表明，它具有显著的保肝作用（p < 0.01）。
