Colmenero J D, Reguera J M, Fernández-Nebro A, Cabrera-Franquelo F
Department of Internal Medicine, Hospital Regional Carlos Haya, Málaga, Spain.
Ann Rheum Dis. 1991 Jan;50(1):23-6. doi: 10.1136/ard.50.1.23.
Two hundred and sixty three patients with a diagnosis of brucellosis between January 1984 and December 1987 were studied prospectively. Sixty five patients (25%) developed osteoarticular complications. These patients had a more prolonged course than those with no complications. Spondylitis in 38 (58%) and sacroiliitis in 29 (45%) were the most prevalent. There were no significant laboratory, serological, or bacteriological differences between patients with and without osteoarticular complications. At diagnosis 47 patients (72%) showed radiographic abnormalities, commonly in axial sites but rarely in peripheral sites. Radionuclide bone scan was positive with no radiographic abnormalities in 17 (26%) of cases. Fifty seven patients received medical treatment alone, 51 (89%) being cured with a single course of treatment. Treatment failed or there was a relapse in six patients (11%), of whom five had spondylitis. Eight of the 65 patients (12%), all of whom had spondylitis and paravertebral or epidural abscesses, also required surgical treatment.
对1984年1月至1987年12月间诊断为布鲁氏菌病的263例患者进行了前瞻性研究。65例患者（25%）出现了骨关节并发症。这些患者的病程比无并发症的患者更长。脊柱炎38例（58%）和骶髂关节炎29例（45%）最为常见。有骨关节并发症和无并发症的患者在实验室检查、血清学检查或细菌学检查方面无显著差异。诊断时47例患者（72%）显示有影像学异常，常见于中轴部位，但很少见于外周部位。17例（26%）病例放射性核素骨扫描呈阳性但无影像学异常。57例患者仅接受药物治疗，51例（89%）经一个疗程治疗后治愈。6例患者（11%）治疗失败或复发，其中5例患有脊柱炎。65例患者中有8例（12%）均患有脊柱炎且伴有椎旁或硬膜外脓肿，还需要手术治疗。
