Centro de Investigación Científica de Yucatán, Calle 43 #130, Col. Chuburná de Hidalgo, Mérida, Yucatán, México.
Phytother Res. 2010 Jul;24(7):1004-8. doi: 10.1002/ptr.3052.
The in vitro leishmanicidal effect of (3S)-16,17-didehydrofalcarinol (1) isolated from Tridax procumbens whole plant against Leishmania mexicana, the causative agent of cutaneous leishmaniasis (chiclero's ulcer) in the New World, was investigated. This oxylipin showed significant in vitro activity against promastigotes and intracellular amastigotes of L. mexicana. Its inhibitory effect on amastigotes was not due to activation of NO in recombinant gamma-interferon-stimulated macrophages, since the production of NO was decreased in presence of the oxylipin. This is the first report on the leishmanicidal activity against the intracellular stage (amastigote) of the oxylipin (3S)-16,17-didehydrofalcarinol.
从三齿猪笼草全草中分离得到的（3S）-16,17-二去氢法卡林醇（1）对新热带地区引起皮肤利什曼病（奇克拉尔溃疡）的利什曼原虫的体外杀利什曼原虫作用进行了研究。这种氧化脂显示出对前鞭毛体和利什曼原虫内阿米巴的显著体外活性。它对阿米巴的抑制作用不是由于重组γ-干扰素刺激的巨噬细胞中 NO 的激活，因为在氧化脂存在的情况下，NO 的产生减少了。这是关于氧化脂（3S）-16,17-二去氢法卡林醇对体内阶段（阿米巴）的杀利什曼原虫活性的首次报道。
