Department of Metabolism and Nutrition, Instituto del Frío, Institute of Food Science and Technology and Nutrition, Spanish National Research Council, 28040 Madrid, Spain.
J Nutr Biochem. 2010 Oct;21(10):948-53. doi: 10.1016/j.jnutbio.2009.07.010. Epub 2009 Dec 1.
The effects of drinking sodium-bicarbonated mineral water on cardiovascular risk in young men and women with moderate cardiovascular risk were studied. Eighteen young volunteers (total cholesterol levels >5.2 mmol/L) without any disease participated. The study consisted of two 8-week intervention periods. Subjects consumed, as supplement to their usual diet, 1 L/day control low mineral water, followed by 1 L/day bicarbonated mineral water (48 mmol/L sodium, 35 mmol/L bicarbonate and 17 mmol/L chloride). Determinations were performed at the end of the control water period and on Weeks 4 and 8 of the bicarbonated water period. Body weight, body mass index (BMI), blood pressure, dietary intake, total cholesterol, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, apolipoprotein (Apo) A-I, Apo B, triacylgycerols, glucose, insulin, adiponectin, high-sensitivity C-reactive protein (hs-CRP), soluble adhesion molecules [soluble intercellular adhesion molecule (sICAM) and soluble vascular adhesion molecule (sVCAM)], sodium and chloride urinary excretion, and urine pH were measured. Dietary intake, body weight and BMI showed no significant variations. Systolic blood pressure decreased significantly after 4 weeks of bicarbonated water consumption, without significant differences between Weeks 4 and 8. After bicarbonated water consumption, significant reductions in total cholesterol (by 6.3%; P=.012), LDL cholesterol (by 10%; P=.001), total/HDL cholesterol (P=.004), LDL/HDL cholesterol (P=.001) and Apo B (P=.017) were observed. Serum triacylglycerol, Apo A-I, sICAM-1, sVCAM-1 and hs-CRP levels did not change. Serum glucose values tended to decrease during the bicarbonated water intervention (P=.056), but insulin levels did not vary. This sodium-bicarbonated mineral water improves lipid profile in moderately hypercholesterolemic young men and women and could therefore be applied in dietary interventions to reduce cardiovascular risk.
研究了饮用含碳酸氢钠矿泉水对心血管风险中等的年轻男性和女性心血管风险的影响。18 名无任何疾病的年轻志愿者（总胆固醇水平>5.2mmol/L）参与了这项研究。研究包括两个 8 周的干预期。受试者在常规饮食的基础上，每天额外补充 1 升对照低矿物质水，然后每天补充 1 升含碳酸氢钠的矿泉水（含 48mmol/L 钠、35mmol/L 碳酸氢盐和 17mmol/L 氯化物）。在对照水期结束时以及含碳酸氢钠水期的第 4 周和第 8 周进行测定。测量体重、体重指数（BMI）、血压、饮食摄入、总胆固醇、低密度脂蛋白（LDL）胆固醇、高密度脂蛋白（HDL）胆固醇、载脂蛋白（Apo）A-I、Apo B、三酰甘油、葡萄糖、胰岛素、脂联素、高敏 C 反应蛋白（hs-CRP）、可溶性细胞间黏附分子（sICAM）和可溶性血管细胞黏附分子（sVCAM）、尿钠和尿氯排泄以及尿 pH。饮食摄入、体重和 BMI 没有明显变化。在饮用含碳酸氢钠水 4 周后，收缩压显著下降，第 4 周和第 8 周之间无显著差异。饮用含碳酸氢钠水后，总胆固醇（降低 6.3%；P=.012）、LDL 胆固醇（降低 10%；P=.001）、总/HDL 胆固醇（P=.004）、LDL/HDL 胆固醇（P=.001）和 Apo B（P=.017）显著降低。血清三酰甘油、Apo A-I、sICAM-1、sVCAM-1 和 hs-CRP 水平没有变化。血清葡萄糖值在饮用含碳酸氢钠水的干预期间有下降趋势（P=.056），但胰岛素水平没有变化。这种含碳酸氢钠的矿泉水可改善血脂谱，改善中度高胆固醇血症的年轻男性和女性的血脂谱，因此可应用于饮食干预，降低心血管风险。
