Department of Gastroenterology Surgery, Xijing Digestive Hospital, The Fourth Military Medical University, Changlexi Road No. 15th, Xi'an, Shaanxi Province, People's Republic of China.
Med Oncol. 2010 Dec;27(4):1273-6. doi: 10.1007/s12032-009-9373-y. Epub 2009 Dec 1.
Colorectal cancer is the second leading cause of cancer-related death in the United States and the fourth leading cause worldwide. Currently, there is still no excellent predictor of the survival. Polycomb-group proteins Bmi1 is regarded as a "stemness" gene involved in the maintenance of stem cells, malignant transformation, and biologic aggressiveness of several human carcinomas. We examined the expression of the Bmi1 in colon cancer and its relevance to other characteristics, especially the 5-year survival of colon cancer. The expression of Bmi1 was examined in colorectal carcinoma (n=98) by using real-time polymerase chain reaction. Expression was correlated with clinicopathologic variables, 5-year overall survival (OS) rates. We for the first time found that high expression of Bmi1 was significantly associated with poor survival. Fourfold Table Chi-square Test analysis revealed that Bmi1 expression was closely related to TNM stage and histologic grade, while not relevant to age. In summary, the high expression of polycomb-group protein Bmi1 is an essential and important predictor of colorectal cancer prognosis.
结直肠癌是美国癌症相关死亡的第二大原因，也是全球癌症相关死亡的第四大原因。目前，仍然没有出色的生存预测指标。多梳蛋白组蛋白 Bmi1 被认为是一种“干性”基因，涉及到维持干细胞、恶性转化和几种人类癌的生物学侵袭性。我们研究了 Bmi1 在结肠癌中的表达及其与其他特征的相关性，特别是结肠癌的 5 年生存率。通过实时聚合酶链反应检测 98 例结直肠癌中 Bmi1 的表达。表达与临床病理变量、5 年总生存率（OS）率相关。我们首次发现，Bmi1 的高表达与不良预后显著相关。四格表卡方检验分析显示，Bmi1 表达与 TNM 分期和组织学分级密切相关，而与年龄无关。总之，多梳蛋白组蛋白 Bmi1 的高表达是结直肠癌预后的一个重要预测指标。
