Pace D, Longfellow M, Bulmer J N
Department of Pathology, University of Leeds, UK.
J Reprod Fertil. 1991 Jan;91(1):165-74. doi: 10.1530/jrf.0.0910165.
Intraepithelial lymphocytes (IELs) were characterized and quantitated in normal non-pregnant endometrium and in early pregnancy decidua using H & E and phloxine tartrazine stains and a panel of monoclonal antibodies in an indirect immunoperoxidase technique. The relative numbers of granulated and non-granulated IELs varied according to menstrual cycle stage and in early pregnancy all IELs appeared to be granulated. There was a higher surface:gland ratio for IELs in proliferative endometrium compared with late secretory phase and early pregnancy endometrium. In proliferative endometrium most IELs were T cells, predominantly of the CD8 + subset. In first trimester decidua, higher numbers of CD56 + cells were observed, in keeping with the increased proportion of granulated IELs. IEL populations in human endometrium vary according to menstrual cycle stage and endometrial IELs appear to show phenotypic differences compared with IELs in the human gastrointestinal tract.
运用苏木精和伊红染色、焰红 - 酒石黄染色以及一组单克隆抗体，采用间接免疫过氧化物酶技术，对正常非妊娠子宫内膜和早孕蜕膜中的上皮内淋巴细胞（IELs）进行特征鉴定和定量分析。颗粒状和非颗粒状IELs的相对数量因月经周期阶段而异，在早孕时所有IELs似乎都是颗粒状的。与分泌晚期和早孕子宫内膜相比，增殖期子宫内膜中IELs的表面与腺体比例更高。在增殖期子宫内膜中，大多数IELs是T细胞，主要是CD8 +亚群。在孕早期蜕膜中，观察到CD56 +细胞数量较多，这与颗粒状IELs比例增加一致。人子宫内膜中的IEL群体因月经周期阶段而异，与人类胃肠道中的IELs相比，子宫内膜IELs似乎表现出表型差异。
