Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA.
Am J Obstet Gynecol. 2011 Oct;205(4):324.e1-7. doi: 10.1016/j.ajog.2011.05.031. Epub 2011 May 20.
The objective of the study was to characterize endometrial inflammation associated with common genital tract pathogens.
The design of the study was the immunohistochemical characterization of the endometrial leukocyte subpopulations from 37 controls and 45 women infected with Chlamydia trachomatis, Neisseria gonorrhoeae, or Trichomonas vaginalis.
Compared with uninfected women, endocervical infection with C trachomatis, N gonorrhoeae, or T vaginalis was associated with significant increases in endometrial T cells, B cells, plasma cells, and polymorphonuclear leukocytes. Even more substantial increases in T cell, B cell, and plasma cell numbers were detected among women infected endocervically and endometrially with C trachomatis.
Because lower genital tract C trachomatis, N gonorrhoeae, or T vaginalis infections were associated with comparable increases in the same endometrial leukocyte subpopulations, our results suggest the underappreciated involvement of T vaginalis in upper genital tract inflammatory processes. The more robust inflammatory infiltrate associated with C trachomatis endometrial ascension may offer insight into host inflammatory responses associated with pelvic inflammatory disease development.
本研究旨在描述与常见生殖道病原体相关的子宫内膜炎症。
本研究通过免疫组织化学方法对 37 名对照和 45 名感染沙眼衣原体、淋病奈瑟菌或阴道毛滴虫的女性的子宫内膜白细胞亚群进行特征描述。
与未感染的女性相比，宫颈内感染沙眼衣原体、淋病奈瑟菌或阴道毛滴虫与子宫内膜 T 细胞、B 细胞、浆细胞和多形核白细胞显著增加有关。在宫颈和子宫内膜同时感染沙眼衣原体的女性中，T 细胞、B 细胞和浆细胞数量的增加更为明显。
由于下生殖道沙眼衣原体、淋病奈瑟菌或阴道毛滴虫感染与相同的子宫内膜白细胞亚群的相似增加有关，我们的结果表明阴道毛滴虫在下生殖道炎症过程中的作用被低估了。与沙眼衣原体子宫内膜上行感染相关的更强烈的炎症浸润可能为与盆腔炎性疾病发展相关的宿主炎症反应提供了新的见解。
