从 Mikania decora 和 Cremastosperma microcarpum 中分离出的细胞毒性和抗传染性酚类化合物。

Cytotoxic and anti-infective phenolic compounds isolated from Mikania decora and Cremastosperma microcarpum.

机构信息

Department of Chemistry, University of Louisville, Louisville, KY, USA.

出版信息

Planta Med. 2011 Sep;77(14):1597-9. doi: 10.1055/s-0030-1270960. Epub 2011 Apr 6.

Abstract

An anticancer-bioassay guided isolation of the ethanol extract and fractions of two plants from the Peruvian rainforest, Mikania decora and Cremastosperma microcarpum, led to the characterization of one abundant diterpene, ent-pimara-8(14),15-dien-19-oic acid (1), three thymol derivatives, 10-acetoxy-8,9-dehydro-6-methoxythymol butyrate (2), 10-acetoxy-8,9-epoxy-6-methoxythymol isobutyrate (3), and acetylschizoginol (4), as well as one neolignan, (±)-trans-dehydrodiisoeugenol (5). Only the latter was isolated from C. microcarpum. These compounds exhibited significant cytotoxic activity against a panel of human tumor cell lines. Compounds 3 and 4 were also investigated for their in vitro antileishmanial and trypanocidal activity against Leishmania amazonensis axenic amastigotes and Trypanosoma cruzi trypomastigotes.

摘要

一种抗癌生物测定指导下，从秘鲁雨林中的两种植物 Mikania decora 和 Cremastosperma microcarpum 中分离出乙醇提取物和馏分，导致鉴定出一种丰富的二萜，ent-pimara-8(14),15-dien-19-oic acid（1），三种麝香草酚衍生物，10-乙酰氧基-8,9-去氢-6-甲氧基麝香草酚丁酸酯（2），10-乙酰氧基-8,9-环氧-6-甲氧基麝香草酚异丁酸酯（3）和乙酰schizoginol（4），以及一种新木脂素，（±）-反式-脱氢二异丁香酚（5）。只有后者从 C. microcarpum 中分离出来。这些化合物对一组人类肿瘤细胞系表现出显著的细胞毒性活性。化合物 3 和 4 还被研究了它们对 Leishmania amazonensis 无细胞内变形体和 Trypanosoma cruzi 锥虫体的体外抗利什曼原虫和杀锥虫活性。