Department of Internal Medicine/Infectious Diseases and Pulmonary Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Thromb Haemost. 2009 Dec;102(6):1103-9. doi: 10.1160/TH09-05-0323.
Bacteraemia and viraemia are characterised by pathogens entering the bloodstream. Endothelial cells are among the first cells coming into contact with the microbes and also some endogenous molecules which are released by tissue damage. As part of the innate immune system, endothelial cells respond to these contacts by producing inflammatory mediators and expressing surface molecules. The initial sensing of microbial and endogenous danger-associated molecules is mediated by so-called pattern recognition receptors (PRRs). PRRs can be classified in different protein families such as the Toll-like receptors, the NOD-like receptors and the RIG-I-like receptors. By activating inflammatory gene transcription and posttranslational processing, PRRs control the immediate innate immune reaction and also the subsequent adaptive immune response. Here we describe the current knowledge of extra- and intracellular PRRs in endothelial cells and their potential role in sepsis and vascular diseases.
菌血症和病毒血症的特征是病原体进入血液。内皮细胞是与微生物和组织损伤释放的某些内源性分子首先接触的细胞之一。作为先天免疫系统的一部分，内皮细胞通过产生炎症介质和表达表面分子来对这些接触作出反应。对微生物和内源性危险相关分子的初始感知是由所谓的模式识别受体（PRRs）介导的。PRRs 可以分为不同的蛋白质家族，如 Toll 样受体、NOD 样受体和 RIG-I 样受体。通过激活炎症基因转录和翻译后加工，PRRs 控制即刻的先天免疫反应和随后的适应性免疫反应。在这里，我们描述了内皮细胞中外源和细胞内 PRRs 的最新知识及其在败血症和血管疾病中的潜在作用。
