Department of Pharmaceutical, Chemical and Environmental Sciences, School of Science, University of Greenwich, Chatham, Kent, UK.
J Mater Sci Mater Med. 2010 Apr;21(4):1249-53. doi: 10.1007/s10856-009-3957-0. Epub 2009 Dec 6.
The potential of employing zinc polycarboxylate dental cement as a controlled release material has been studied. Benzalkonium chloride was used as the active ingredient, and incorporated at concentrations of 1, 2 and 3% by mass within the cement. At these levels, there was no observable effect on the speed of setting. Release was followed using an ion-selective electrode to determine changes in chloride ion concentration with time. This technique showed that the additive was released when the cured cement was placed in water, with release occurring by a diffusion mechanism for the first 3 h, but continuing beyond that for up to 1 week. Diffusion coefficients were in the range 5.62 x 10(-6) cm(2) s(-1) (for 1% concentration) to 10.90 x 10(-6) cm(2) s(-1) (for 3% concentration). Up to 3% of the total loading of benzalkonium chloride was released from the zinc polycarboxylate after a week, which is similar to that found in previous studies with glass-ionomer cement. It is concluded that zinc polycarboxylate cement is capable of acting as a useful material for the controlled release of active organic compounds.
研究了锌多羧酸酯牙科水泥作为控制释放材料的潜力。使用苯扎氯铵作为活性成分，并以质量浓度 1%、2%和 3%掺入水泥中。在这些水平下，凝固速度没有观察到明显的影响。使用离子选择性电极跟踪释放情况，以确定氯离子浓度随时间的变化。该技术表明，当固化的水泥被放置在水中时，添加剂会被释放出来，在最初的 3 小时内通过扩散机制释放，但在那之后持续释放长达 1 周。扩散系数在 5.62 x 10(-6) cm(2) s(-1)（1%浓度）到 10.90 x 10(-6) cm(2) s(-1)（3%浓度）之间。在一周后，从锌多羧酸酯中释放出了高达 3%的苯扎氯铵总加载量，与之前玻璃离子水泥的研究结果相似。结论是，锌多羧酸酯水泥能够作为一种有用的材料，用于控制释放活性有机化合物。
