Nicol M E, Moriarty J, Edwards J, Robbie D S, A'Hern R P
Royal Marsden Hospital, London.
Anaesthesia. 1991 Jan;46(1):67-9. doi: 10.1111/j.1365-2044.1991.tb09323.x.
Pain on injection of propofol was assessed in a controlled, randomised study of 273 patients. They received either lignocaine 10 mg, procaine 10 mg or isotonic saline 0.5 ml, 15 seconds before the injection of propofol into a vein on the back of the hand. The incidence of pain on injection in the control group (51%) was comparable with other studies. Lignocaine and procaine both significantly reduced the pain (35% and 34% respectively, p less than 0.05) but there was no statistical difference between these two groups.
在一项针对273名患者的对照随机研究中，评估了丙泊酚注射时的疼痛情况。在将丙泊酚注入手背静脉前15秒，他们分别接受了10毫克利多卡因、10毫克普鲁卡因或0.5毫升等渗盐水。对照组注射时的疼痛发生率（51%）与其他研究相当。利多卡因和普鲁卡因均显著减轻了疼痛（分别为35%和34%，p<0.05），但这两组之间无统计学差异。
