Tham C S, Khoo S T
National University Hospital, Singapore.
Anaesth Intensive Care. 1995 Apr;23(2):154-7. doi: 10.1177/0310057X9502300204.
Pain is a well known complication of propofol injection. Premixing with lignocaine 0.1 mg.kg-1 and injection into a large forearm vein has been recommended. The amount of lignocaine to be added is often empirical when the vein on the dorsum of the hand is used. In this study we attempt to determine the optimal amount of lignocaine necessary to reduce pain when propofol is injected into a hand vein. Our study shows that a propofol emulsion containing 0.05% lignocaine is effective in reducing the incidence of propofol injection pain. The addition of lignocaine also reduces the incidence of excitatory effects. Increasing the dosage of lignocaine above 0.05% does not improve the results.
疼痛是丙泊酚注射常见的并发症。有人建议将丙泊酚与0.1mg/kg的利多卡因预混后注入较大的前臂静脉。当使用手背静脉时，利多卡因的添加量通常凭经验确定。在本研究中，我们试图确定将丙泊酚注入手部静脉时减轻疼痛所需的利多卡因最佳剂量。我们的研究表明，含0.05%利多卡因的丙泊酚乳剂能有效降低丙泊酚注射疼痛的发生率。添加利多卡因还可降低兴奋效应的发生率。将利多卡因剂量增加至0.05%以上并不能改善效果。
