Barker P, Langton J A, Murphy P, Rowbotham D J
Department of Anaesthesia, Leicester Royal Infirmary.
Anaesthesia. 1991 Dec;46(12):1069-70. doi: 10.1111/j.1365-2044.1991.tb09927.x.
A single-blind, randomised, controlled study was undertaken to compare the efficacy of three methods of preventing pain during injection of propofol on induction of anaesthesia. Patients were allocated randomly to receive unmodified propofol, propofol with 0.05% lignocaine, propofol at 4 degrees C and unmodified propofol preceded by 10 ml of 0.9% saline at 4 degrees C. Prior injection of cold saline reduced the incidence of pain and discomfort significantly (22%) compared with unmodified propofol (75%; p less than 0.005) and was similar to that after cold propofol (33%) and propofol with lignocaine (44%). There was no significant difference between the treatment groups.
进行了一项单盲、随机、对照研究，以比较三种在丙泊酚诱导麻醉注射时预防疼痛方法的疗效。患者被随机分配接受未改性丙泊酚、含0.05%利多卡因的丙泊酚、4℃的丙泊酚以及先注射10ml 4℃的0.9%盐水再注射未改性丙泊酚。与未改性丙泊酚（75%；p<0.005）相比，预先注射冷盐水显著降低了疼痛和不适的发生率（22%），且与冷丙泊酚（33%）和含利多卡因的丙泊酚（44%）后的发生率相似。各治疗组之间无显著差异。
