Gehan G, Karoubi P, Quinet F, Leroy A, Rathat C, Pourriat J L
Département d'Anesthésie-Réanimation, CHU Avicenne-Jean Verdier, Université Paris XIII, Bobigny, France.
Br J Anaesth. 1991 Mar;66(3):324-6. doi: 10.1093/bja/66.3.324.
The purpose of this study was to define the optimum dose of lignocaine required to reduce pain on injection of propofol. We conducted a prospective, randomized, double-blind trial on 310 patients undergoing anaesthesia. Patients were allocated to four groups according to the lignocaine dosage: group A (control), no lignocaine; group B, lignocaine 0.1 mg kg-1; group C, lignocaine 0.2 mg kg-1; group D, lignocaine 0.4 mg kg-1. Our results showed that a dose of lignocaine 0.1 mg kg-1 significantly reduced the incidence of pain and that there was no improvement when the dose was increased.
本研究的目的是确定在注射丙泊酚时减轻疼痛所需的利多卡因最佳剂量。我们对310例接受麻醉的患者进行了一项前瞻性、随机、双盲试验。根据利多卡因剂量将患者分为四组：A组（对照组），不使用利多卡因；B组，利多卡因0.1mg/kg；C组，利多卡因0.2mg/kg；D组，利多卡因0.4mg/kg。我们的结果表明，0.1mg/kg的利多卡因剂量可显著降低疼痛发生率，且剂量增加时并无改善。
