Gao Shu-Shan, Li Xiao-Ming, Wang Bin-Gui
Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China.
Nat Prod Commun. 2009 Nov;4(11):1477-80.
Two new perylene derivatives, 7-epi-8-hydroxyaltertoxin I (1) and 6-epi-stemphytriol (2), along with two known compounds stemphyperylenol (3) and altertoxin I (4) were isolated from Alternaria alternata, a marine endophytic fungus derived from an unidentified algal species of the genus Laurencia. Structures of compounds 1-4 were determined on the basis of detailed spectroscopic analysis, as well as by comparison with literature reports. The antimicrobial activities of compounds 1 and 3 against Staphylococcus aureus, Escherichia coli, and Aspergillus niger were evaluated; neither showed obvious activity.
从一种源自未鉴定的劳伦氏藻属藻类的海洋内生真菌链格孢中分离出两种新的苝衍生物，7-表-8-羟基交替毒素I（1）和6-表-匍柄霉三醇（2），以及两种已知化合物匍柄苝醇（3）和交替毒素I（4）。化合物1-4的结构通过详细的光谱分析以及与文献报道进行比较来确定。评估了化合物1和3对金黄色葡萄球菌、大肠杆菌和黑曲霉的抗菌活性；两者均未表现出明显活性。
