Chiang Yi-Ming, Lee Kuan-Han, Sanchez James F, Keller Nancy P, Wang Clay C C
Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, Los Angeles 90033, California, USA.
Nat Prod Commun. 2009 Nov;4(11):1505-10.
Recent published sequencing of fungal genomes has revealed that these microorganisms have a surprisingly large number of secondary metabolite pathways that can serve as potential sources for new and useful natural products. Most of the secondary metabolites and their biosynthesis pathways are currently unknown, possibly because they are produced in very small amounts and are thus difficult to detect or are produced only under specific conditions. Elucidating these fungal metabolites will require new molecular genetic tools, better understanding of the regulation of secondary metabolism, and state of the art analytical methods. This review describes recent strategies to mine the cryptic natural products and their biosynthetic pathways in fungi.
最近发表的真菌基因组测序结果表明，这些微生物拥有数量惊人的次生代谢产物途径，可作为新的和有用的天然产物的潜在来源。目前，大多数次生代谢产物及其生物合成途径尚不清楚，这可能是因为它们的产量极少，难以检测，或者仅在特定条件下产生。阐明这些真菌代谢产物需要新的分子遗传学工具、对次生代谢调控的更好理解以及先进的分析方法。本综述描述了挖掘真菌中隐秘天然产物及其生物合成途径的最新策略。
