Institute for Aging Research, Hebrew SeniorLife, 1200 Centre Street, Boston, MA 02131, USA.
Curr Osteoporos Rep. 2009 Dec;7(4):134-9. doi: 10.1007/s11914-009-0023-2.
Experimental studies indicate that the proinflammatory cytokines interleukin-1, interleukin-6, and tumor necrosis factor-alpha are important regulators of bone resorption and may play an important role in age- and estrogen deficiency-related bone loss. Although the observation of accelerated bone loss in patients with inflammatory disorders supports this mechanism, the role of cytokines in the etiology of osteoporosis has yet to be determined. Elucidation of this potential relationship could not only provide clinicians with an additional tool to identify patients at risk for osteoporosis, but may also inform the development of cytokine-blocking therapies as potential interventions to curb bone loss. Although some epidemiologic studies suggest increases in proinflammatory cytokines are associated with decreased bone mass and greater fracture risk, the totality of evidence is limited and provides no clear indication of which cytokines may be most important for bone health. Additional studies are required to establish if inflammation is an important risk factor for osteoporosis.
实验研究表明，促炎细胞因子白细胞介素-1、白细胞介素-6 和肿瘤坏死因子-α 是骨吸收的重要调节剂，可能在与年龄和雌激素缺乏相关的骨丢失中发挥重要作用。虽然观察到炎症性疾病患者的骨丢失加速支持了这一机制，但细胞因子在骨质疏松症发病机制中的作用仍有待确定。阐明这种潜在的关系不仅可以为临床医生提供另一种识别骨质疏松症高危患者的工具，还可能为细胞因子阻断疗法的发展提供信息，作为抑制骨丢失的潜在干预措施。尽管一些流行病学研究表明促炎细胞因子的增加与骨量减少和骨折风险增加有关，但证据的总体情况有限，并且不能明确表明哪些细胞因子对骨骼健康最重要。需要进一步的研究来确定炎症是否是骨质疏松症的一个重要危险因素。
