Kim Beom-Jun, Yu Yong Mi, Kim Euy Nyong, Chung Yun-Ey, Koh Jung-Min, Kim Ghi Su
Division of Endocrinology and Metabolism, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
Clin Endocrinol (Oxf). 2007 Jul;67(1):152-8. doi: 10.1111/j.1365-2265.2007.02853.x. Epub 2007 Apr 27.
Although osteoporosis and atherosclerosis seem to be related, the mechanisms are not yet understood. We previously observed that women with higher serum concentrations of high sensitivity C-reactive protein (hsCRP), a strong risk factor for atherosclerosis, had lower bone mineral density (BMD). However, the relationship of hsCRP level with bone turnover rate, an independent risk factor for osteoporotic fracture, is not known.
Cross-sectional hospital-based survey.
Apparently healthy pre- and postmenopausal women (n = 39 and 150, respectively).
Urinary N-terminal telopeptide of type I collagen (NTx) and serum bone specific alkaline phosphatase (BALP) were measured using commercially available immunoassay kits. Serum hsCRP concentrations were measured by a particle-enhanced immunoturbidometric method.
Both urinary NTx (gamma = 0.288, P < 0.001) and serum BALP (gamma = 0.260, P < 0.001) were positively correlated with serum hsCRP levels. Significance remained even after adjustment for age, body mass index and years since menopause (gamma = 0.257, P < 0.001, and gamma = 0.163, P = 0.027, respectively). Compared with subjects in the lowest hsCRP quartile (< or = 0.6 mg/l), those in the highest hsCRP quartile (> or = 1.6 mg/l) had significantly higher urinary NTx concentrations (P = 0.001) after adjustment for confounding variables. There was an increasing trend of serum BALP concentrations in the higher hsCRP quartile groups (P = 0.073).
These findings suggest that low grade systemic inflammation may be a common linking factor between development of atherosclerosis and increased bone turnover rate.
虽然骨质疏松症和动脉粥样硬化似乎有关联，但其机制尚不清楚。我们之前观察到，血清高敏C反应蛋白（hsCRP，动脉粥样硬化的一个强风险因素）浓度较高的女性骨矿物质密度（BMD）较低。然而，hsCRP水平与骨质疏松性骨折的一个独立风险因素——骨转换率之间的关系尚不清楚。
基于医院的横断面调查。
明显健康的绝经前和绝经后女性（分别为39例和150例）。
使用市售免疫分析试剂盒测量尿I型胶原N端肽（NTx）和血清骨特异性碱性磷酸酶（BALP）。血清hsCRP浓度通过颗粒增强免疫比浊法测量。
尿NTx（γ = 0.288，P < 0.001）和血清BALP（γ = 0.260，P < 0.001）均与血清hsCRP水平呈正相关。即使在调整年龄、体重指数和绝经年限后，相关性仍具有统计学意义（分别为γ = 0.257，P < 0.001和γ = 0.163，P = 0.027）。与hsCRP四分位数最低组（≤0.6 mg/l）的受试者相比，在调整混杂变量后，hsCRP四分位数最高组（≥1.6 mg/l）的受试者尿NTx浓度显著更高（P = 0.001）。hsCRP四分位数较高组的血清BALP浓度有上升趋势（P = 0.073）。
这些发现表明，低度全身炎症可能是动脉粥样硬化发展和骨转换率增加之间的一个共同联系因素。
