Scott N, Sagar P, Stewart J, Blair G E, Dixon M F, Quirke P
Department of Pathology, University of Leeds, UK.
Br J Cancer. 1991 Feb;63(2):317-9. doi: 10.1038/bjc.1991.74.
p53 protein was detected by immunohistochemistry in 42% of 52 colorectal adenocarcinomas. Positive tumours were significantly more frequent in the distal colon, and demonstrated a higher rate of cell proliferation. No correlation was found with tumour grade, Dukes' stage, presence of DNA aneuploidy or patient survival. The role of p53 in colorectal carcinogenesis is discussed with particular reference to differences between proximal and distal large bowel cancers.
采用免疫组织化学方法在52例结肠腺癌中检测到42%存在p53蛋白。阳性肿瘤在结肠远端更为常见，且细胞增殖率更高。未发现与肿瘤分级、Dukes分期、DNA非整倍体的存在或患者生存率相关。特别参照近端和远端大肠癌之间的差异，讨论了p53在结直肠癌发生中的作用。
