当前和既往吸食 crack 可卡因者的神经心理学评估。
Neuropsychological assessment of current and past crack cocaine users.
机构信息
Department of Psychiatry, Medical School, Universidade de São Paulo (USP), São Paulo (SP), Brazil.
出版信息
Subst Use Misuse. 2009;44(13):1941-57. doi: 10.3109/10826080902848897.
BACKGROUND
Cognitive changes due to crack cocaine consumption remain unclear.
METHODS
For clarification, 55 subjects were assigned to three groups: control group, crack cocaine current users, and ex-users. Participants were submitted to Mini-Mental State Examination (MMSE) and tasks evaluating executive functioning and verbal memory. Mood state was also measured. Intergroup comparisons were carried out.
RESULTS
Control group performance on the MMSE was better than that of users and ex-users. Verbal memory performance for logical memory of users was impaired. Ex-users scored lower on DSST and Trail Making Test (Part B).
CONCLUSION
Chronic crack cocaine use seems to disrupt general cognitive functioning (MMSE), verbal memory, and attentional resources, but findings suggest that some of these effects could be reversed by abstinence.
背景
由于吸食强效可卡因而导致的认知变化仍不清楚。
方法
为了澄清这一点，将 55 名受试者分为三组：对照组、强效可卡因现用者组和曾用者组。参与者接受了简易精神状态检查（MMSE）和评估执行功能和言语记忆的任务。同时还测量了情绪状态。进行了组间比较。
结果
对照组在 MMSE 上的表现优于使用者和曾用者。使用者的逻辑记忆言语记忆受损。曾用者在数字符号转换测试（DSST）和连线测试（Part B）中的得分较低。
结论
慢性吸食强效可卡因似乎会破坏一般认知功能（MMSE）、言语记忆和注意力资源，但研究结果表明，这些影响中的一些可能会因戒除而逆转。
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