Department of Pediatrics, Division of Pediatric Allergy & Immunology, Duke University School of Medicine, Durham, NC, USA.
Curr Allergy Asthma Rep. 2012 Dec;12(6):621-9. doi: 10.1007/s11882-012-0296-x.
In the US and other developed countries, food allergy is a growing epidemic in pediatric populations with a substantial impact on health-related quality of life. As such, there are great efforts underway to unravel the mechanisms of oral mucosal tolerance and to better define the factors related to host and allergen exposure that contribute to the aberrant immune response leading to sensitization and clinical food allergy. Although more research is needed to eventually develop targeted treatment and prevention strategies, this review highlights our current understanding of the pathogenesis of IgE-mediated food allergy.
在美国和其他发达国家，食物过敏是儿科人群中日益严重的流行疾病，对与健康相关的生活质量有重大影响。因此，人们正在努力揭示口腔黏膜耐受的机制，并更好地定义与宿主和过敏原暴露相关的因素，这些因素导致异常免疫反应，从而导致致敏和临床食物过敏。尽管需要更多的研究来最终开发有针对性的治疗和预防策略，但本综述强调了我们目前对 IgE 介导的食物过敏发病机制的理解。
